The Treatment of Bacterial Pneumonia With Erythromycin: A Controlled Clinical Study

Article1 July 1954THE TREATMENT OF BACTERIAL PNEUMONIA WITH ERYTHROMYCIN: A CONTROLLED CLINICAL STUDYCOUNT D. GIBSON JR., M.D., HARRY NUSHAN, M.D., DAN N. ANDERSON, M.D.COUNT D. GIBSON JR., M.D.Search for more papers by this author, HARRY NUSHAN, M.D.Search for more papers by this author, DAN N. ANDERSON, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-41-1-112 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTwenty years ago no specific agent (with the exception of antiserum) was available for the treatment of pneumococcal pneumonia. Today the physician is confronted with a variety of drugs which can favorably modify this disease. The sulfonamides,1 penicillin,2 bacitracin,3 chlortetracycline,2 oxytetracycline4 and chloramphenicol2 are all of proved clinical value. Of these, none has been proved more efficacious or in general less toxic than penicillin.In 1952 a new antibiotic, erythromycin, was made available for clinical study.5In vitro studies indicated that the pneumococcus was inhibited by 0.1 microgram/ml. of the drug. Several case reports suggested that good results were obtained...Bibliography1. PetersonFinland OLM: The modern treatment of pneumonia, M. Clin. North America 27: 1291-1307 (Sept.) 1943. CrossrefGoogle Scholar2. FlippinMatteucciSchimmelBoger HFWVNHWB: Aureomycin, chloramphenicol, and penicillin bacterial pneumonia, J. A. M. A. 147: 918-921 (Nov. 3) 1951. CrossrefMedlineGoogle Scholar3. ReisnerBaileyAppelbaum EHFNE: The treatment of pneumonia with bacitracin, Ann. Int. Med. 34: 1232-1242 (May) 1951. LinkGoogle Scholar4. MelcherGibsonRoseKneeland GWCDHMY: Terramycin in the treatment of pneumococcic and primary atypical pneumonia, J. A. M. A. 143: 1303-1308 (Aug. 12) 1950. CrossrefMedlineGoogle Scholar5. McGuireBunchAndersonBoazFlynnPowellSmith JMRLRCHEEHHMJW: "Ilotycin, " a new antibiotic, Antibiotics and Chemotherapy 2: 281 (June) 1952. Google Scholar6. HaightFinland THM: Laboratory and clinical observations on erythromycin, New England J. Med. 247: 227 (Aug. 14) 1952. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: *Received for publication January 8, 1954.From the Medical Services of the Medical College of Virginia Hospital, Kecoughtan Veterans Administration Hospital, McGuire Veterans Administration Hospital and the Department of Medicine, Medical College of Virginia.Sponsored by the Veterans Administration and published with the approval of the Chief Medical Director. The statements and conclusions published by the authors are a result of their own study and do not necessarily reflect the opinion or policy of the Veterans Administration.Partial support for this study and a supply of erythromycin were generously supplied by Abbott Laboratories, North Chicago, Illinois. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byErythromycin: A Microbial and Clinical Perspective After 30 Years of Clinical Use (Second of Two Parts)Erythromycin and Related Antibiotics: Applied PharmacologyAntibiotics: Use Versus Abuse 1 July 1954Volume 41, Issue 1Page: 112-117KeywordsAntibioticsBacterial pneumoniaDrugsErythromycinHospital medicineMedical servicesPenicillinPneumococcusPneumonia ePublished: 1 December 2008 Issue Published: 1 July 1954 PDF downloadLoading ...