β1-Subunits Increase Surface Expression of a Large-Conductance Ca2+-Activated K+ Channel Isoform

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Population

HEK293T cells and embryonic day 9 chick ciliary ganglion neurons

Comparison

Co-expression or overexpression of avian… vs Expression of VEDEC isoform alone or with…

Design

Preclinical

Authors

Discussion

Does not support clinical translation; leaves open whether avian beta1 trafficking effects extend to mammalian cardiovascular BK channels.

Population

HEK293T cells and embryonic day 9 chick ciliary ganglion neurons

Intervention

Co-expression or overexpression of avian beta1-subunits or its N-terminal domain

Comparator

Expression of VEDEC isoform alone or with C-terminal/extracellular loop domains

Outcome

Surface expression of BK(Ca) channelssurrogate

Avian beta1-subunits stimulate the trafficking of BK(Ca) channels to the plasma membrane, increasing surface expression and macroscopic currents.

Kim et al. (2007) studied this question.

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Does not support clinical translation; leaves open whether avian beta1 trafficking effects extend to mammalian cardiovascular BK channels.