What question did this study set out to answer?

To assess the relationship between the ERBB4 rs13393577 gene polymorphism and breast cancer risk.

Assessment of the Relationship Between ERBB4 rs13393577 Polymorphism and Breast Cancer Susceptibility in Iranian Population

View Full Paper

Ask AI

Bookmark

To assess the relationship between the ERBB4 rs13393577 gene polymorphism and breast cancer risk.
Case-control study conducted in Iran with 110 breast cancer patients and 110 healthy controls (N=220).
DNA was extracted from blood samples, and rs13393577 genotyping was performed via tetra-ARMS-PCR.
Genotype and allele frequencies were analyzed using statistical tests including t-tests.
Genotype frequencies for TT, CT, and CC were 73%, 15%, and 1.8% in patients versus 86%, 11%, and 0.9% in controls.
Allele frequencies were 95% T and 5% C in breast cancer patients versus 97% T and 3% C in healthy controls.
Risk assessment yielded an OR of 3.06 (95% CI, 0.31–29.94) for the T allele and an OR of 0.32 (95% CI, 0.03–3.19) for the C allele, demonstrating no statistically significant difference between groups (P > 0.05).

No takes yet. Share an insight, caveat, or question.

Case-control study observes no significant association between ERBB4 rs13393577 and breast cancer, indicating it is not a predisposing factor.

Eetezadi et al. (2021) studied this question.

View Full Paper

Ask AI

Bookmark

Case-control study observes no significant association between ERBB4 rs13393577 and breast cancer, indicating it is not a predisposing factor.