Why the study?
Are serum levels of anti-inflammatory cytokines (IL-10 and TGF-beta1) associated with carotid intima-media thickness?
Are serum levels of anti-inflammatory cytokines (IL-10 and TGF-beta1) associated with carotid intima-media thickness?
Lower serum IL-10 levels are associated with increased carotid intima-media thickness, suggesting a potential protective role of this anti-inflammatory cytokine against subclinical atherosclerosis.
May indicate IL-10's protective role in carotid atherosclerosis; cross-sectional data leave causal inference and intervention effects open.
Some studies have shown correlations between selected proinflammatory factors and carotid atherosclerosis. It has not been established whether anti-inflammatory cytokines are associated with carotid intima-media thickness (IMT), an ultrasound surrogate marker of atherosclerosis. Therefore, the authors studied the relationship between the carotid IMT and serum levels of interleukin (IL)-10 and transforming growth factor-beta1 in 76 subjects. They discovered that lower IL-10 levels were associated with increased mean IMT in common carotid arteries.
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Ambrosius et al. (2006) studied this question.
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