Electron cryotomography reveals that the fission yeast actomyosin ring consists of a loose bundle of straight, overlapping actin filaments that do not directly contact the membrane.
Provides fundamental structural insights into actomyosin ring mechanics that should not yet change clinical practice; leaves open how these.
for direct 3D imaging by electron cryotomography. Our results show that straight, overlapping actin filaments, running nearly parallel to each other and to the membrane, form a loose bundle of ∼150 nm in diameter that "saddles" the inward-bending membrane at the leading edge of the division septum. The filaments do not make direct contact with the membrane. Our analysis of the actin filaments reveals the variability in filament number, nearest-neighbor distances between filaments within the bundle, their distance from the membrane, and angular distribution with respect to the membrane.
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Swulius et al. (2018) studied this question.
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