Why the study?
The prognostic value of estimated glucose disposal rate (eGDR) in non-ST-segment elevation acute coronary syndrome (NSTE-ACS) following PCI was unknown.
Does estimated glucose disposal rate predict major adverse cardiac and cerebral events in patients with NSTE-ACS undergoing PCI?
Does estimated glucose disposal rate predict major adverse cardiac and cerebral events in patients with NSTE-ACS undergoing PCI?
Low estimated glucose disposal rate based on waist circumference independently predicts major adverse cardiac and cerebral events in patients with NSTE-ACS undergoing PCI.
Waist circumference-based estimated glucose disposal rate may help risk-stratify NSTE-.
Background: Estimated glucose disposal rate (eGDR) is highly associated with all-cause mortality in type 2 diabetes mellitus (T2DM) cases undergoing coronary artery bypass grafting (CABG). Nevertheless, eGDR’s prognostic value in non-ST-segment elevation acute coronary syndrome (NSTE-ACS) following percutaneous coronary intervention (PCI) remains unknown. Methods: The population of this retrospective cohort study comprised NSTE-ACS patients administered PCI in Beijing Anzhen Hospital between January and December 2015. The primary endpoint was major adverse cardiac and cerebral events (MACCEs). eGDR was calculated based on waist circumference (WC) (eGDRWC) or body mass index (BMI) (eGDRBMI). Results: Totally 2308 participants were included, and the mean follow-up time was 41.06 months. The incidence of MACCEs was markedly increased with decreasing eGDR. Multivariable analysis showed hazard ratios (HRs) for eGDRWC and eGDRBMI of 1.152 (95% confidence interval [CI] 1.088–1.219; p < 0.001) and 0.998 (95% CI 0.936–1.064; p = 0.957), respectively. Addition of eGDRWC to a model that included currently recognized cardiovascular risk factors markedly enhanced its predictive power compared with the baseline model (Harrell’s C-index, eGDRWC versus Baseline model, 0.778 versus 0.768, p = 0.003; continuous net reclassification improvement (continuous-NRI) of 0.125, p < 0.001; integrated discrimination improvement (IDI) of 0.016, p < 0.001). Conclusions: Low eGDR independently predicts low survival of NSTE-ACS cases who underwent PCI.
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Liu et al. (2023) studied this question.
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