Why the study?
Various methods used to quantify and describe nitric oxide-dependent cutaneous vasodilation during local heating protocols may impact data interpretation.
The choice of mathematical approach for quantifying NO-dependent cutaneous vasodilation significantly impacts data interpretation and reproducibility.
Local heating protocols are commonly used in conjunction with intradermal microdialysis for assessing nitric oxide (NO)-dependent microvascular function in humans, but various methods used to quantify and describe NO-dependent vasodilation may impact data interpretation. We compared four approaches for quantifying NO-dependent cutaneous vasodilation during local heating at 39°C and 42°C. We identify discrepancies in calculated NO-dependent dilation responses that are dependent upon the mathematical approach and meaningfully impact data interpretation and reproducibility.
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Wolf et al. (2024) studied this question.
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