May 28, 2009Cardiovascular ResearchOpen Access

Heart rate reduction with ivabradine improves energy metabolism and mechanical function of isolated ischaemic rabbit heart

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Population

Langendorff-perfused rabbit heart model subjected to low-flow ischaemia and reperfusion

Comparison

Ivabradine (3 microM) vs Vehicle

Design

Preclinical

Follow-up

30 min reperfusion

Authors

CCClaudio CeconiHeart Failure & Transplant ACAnna CargnoniFondazione Poliambulanza Istituto Ospedaliero GFGloria FrancoliniIstituti Clinici Scientifici Maugeri

Discussion

Member takes

Implication

May attenuate ischaemia-reperfusion injury in isolated hearts; hypothesis-generating for clinical translation.

Structured PICO

Population

Langendorff-perfused rabbit heart model subjected to low-flow ischaemia and reperfusion

Intervention

Ivabradine (3 microM)

Comparator

Vehicle

Outcome

Cardiac energy metabolism (high-energy phosphate contents, mitochondrial respiration, redox potentials) and mechanical function (recovery of developed pressure, diastolic pressure, creatine kinase release, noradrenaline release) after 30 min reperfusionsurrogate

In an isolated ischaemic rabbit heart model, heart rate reduction with ivabradine significantly improved energy metabolism and mechanical function during reperfusion.

Cite This Study

Ceconi et al. (2009) studied this question.

synapsesocial.com/papers/6a8d2e4ef49b7a86957fe8ab https://doi.org/10.1093/cvr/cvp158

View Full Paper

Ask AI

Bookmark

Heart rate reduction with ivabradine improves energy metabolism and mechanical function of isolated ischaemic rabbit heart

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Heart rate reduction with ivabradine improves energy metabolism and mechanical function of isolated ischaemic rabbit heart

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider