Why the study?
Do cranberry proanthocyanidins exhibit cytotoxicity and sensitize platinum-resistant ovarian cancer cells to paraplatin?
Population
Platinum-resistant human ovarian, neuroblastoma, and prostate cancer cell lines, and lung fibroblast cells
Comparison
Cranberry proanthocyanidins alone or in… vs Paraplatin alone or untreated cells
Design
Preclinical
Authors
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Selective in vitro activity against ovarian cancer cells; leaves open translation to in vivo or clinical settings.
Do cranberry proanthocyanidins exhibit cytotoxicity and sensitize platinum-resistant ovarian cancer cells to paraplatin?
Cranberry proanthocyanidins demonstrate selective in vitro cytotoxicity against certain cancer cell lines and sensitize platinum-resistant ovarian cancer cells to paraplatin.
Singh et al. (2009) studied this question.
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