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August 25, 2026International Journal of Polymeric Materials

Polysaccharide-based colon targeting drug delivery systems: Overview on challenges, opportunities and prospects

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Authors

EREkta RathoreNANidhi AgrawalMSMohammad Akbar Siddiqui

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Overview

Review highlights polysaccharide-based mechanisms for targeted colon drug delivery in gastrointestinal disorders, suggesting improved therapeutic efficacy and minimized systemic adverse effects.

Key Points

  • To comprehensively evaluate advancements, mechanisms, and challenges of polysaccharide-based colon-targeted drug delivery systems for treating gastrointestinal diseases.
  • Reviewed polysaccharide carriers, including pectin, chitosan, guar gum, sodium alginate, and hyaluronic acid, used in targeted formulations.
  • Analyzed targeting strategies including pH-sensitive, time-dependent, microbiota-dependent, prodrug, and combination delivery systems.
  • Polysaccharide-based carriers shield acid- and enzyme-sensitive drugs from upper gastrointestinal degradation while bypassing hepatic first-pass metabolism.
  • Microbiota- and pH-responsive formulations enable site-specific sustained drug release in the colon, enhancing localized therapy for ulcerative colitis, Crohn's disease, and colorectal cancer.

Cite This Study

Rathore et al. (2026) studied this question.

synapsesocial.com/papers/6a8d49f7e8bd2413309bbd7fhttps://doi.org/10.1080/00914037.2026.2720624
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