Asymptomatic tuberculosis: new insights and knowledge gaps

Q: What does this research mean for the field?

There are significant knowledge gaps and emerging insights regarding the epidemiology, diagnosis, and management of asymptomatic tuberculosis. Novelty: ClaimNovelty.SYNTHESIS. Consensus alignment: ConsensusAlignment.NEUTRAL.

Alvin Kuo Jing Teo; Thanh Van Nguyen; Emily MacLean; Thu Anh Nguyen; Greg J Fox; Ben J Marais

doi:10.1093/ajrccm/aamag444

August 22, 2026American Journal of Respiratory and Critical Care Medicine

Asymptomatic tuberculosis: new insights and knowledge gaps

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Key Points

Synthesize emerging evidence on asymptomatic and subclinical tuberculosis and identify critical knowledge gaps in detection, pathology, and transmission.
Narrative synthesis of recent clinical, epidemiological, and diagnostic literature regarding asymptomatic Mycobacterium tuberculosis infection.
Asymptomatic and subclinical states represent a substantial portion of the tuberculosis disease spectrum and contribute meaningfully to ongoing transmission.
Current symptom-based screening approaches fail to capture individuals without classic symptoms, underscoring the need for sensitive diagnostic tools and targeted active screening.

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Implication

Expert review uncovers clinical and epidemiological characteristics of asymptomatic tuberculosis, highlighting the need for improved screening strategies.

Abstract

Alvin Kuo Jing Teo, Thanh Van Nguyen, Emily L MacLean, Thu Anh Nguyen, Greg J Fox, Ben J Marais; Asymptomatic tuberculosis: new insights and knowledge gaps

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Cite This Study

Teo et al. (2026) studied this question.

synapsesocial.com/papers/6a8d4a15e8bd2413309bbe68 https://doi.org/10.1093/ajrccm/aamag444

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Asymptomatic tuberculosis: new insights and knowledge gaps

Key Points

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Implication

Abstract

Discussion

Cite This Study

Asymptomatic tuberculosis: new insights and knowledge gaps

Key Points

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Implication

Abstract

Discussion

Cite This Study

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