Association of AP-1/c-Jun with IL-6 and IL-8 expression in hepatocellular carcinoma: attenuating effects of metformin in vitro

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Metformin attenuates the expression of inflammatory cytokines IL-6 and IL-8, as well as AP-1/c-Jun, in hepatocellular carcinoma cells in vitro. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

Tuğba Soydaş; Merve Eskici; Matem Tunçdemi̇r

doi:10.17944/interdiscip.1833817

August 23, 2026Interdisciplinary Medical Journal

Association of AP-1/c-Jun with IL-6 and IL-8 expression in hepatocellular carcinoma: attenuating effects of metformin in vitro

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Key Points

To investigate the therapeutic effects of metformin on the expression of c-Jun and key inflammatory cytokines involved in hepatocellular carcinoma progression.
Treated HepG2 human hepatocellular carcinoma cells with metformin at concentrations ranging from 500 μM to 10 mM for 24 hours.
Evaluated cell viability via trypan blue exclusion, quantified IL-6 and IL-8 concentrations using ELISA, and assessed c-Jun protein expression via immunocytochemistry.
Metformin treatment induced a significant, concentration-dependent reduction in the secretion of inflammatory cytokines IL-6 and IL-8 in HepG2 cells compared to untreated controls.
Metformin administration led to a noticeable decrease in c-Jun protein expression, indicating suppression of AP-1-mediated inflammatory signaling.

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Implication

In vitro study reveals that metformin downregulates IL-6, IL-8, and c-Jun in liver cancer cells, highlighting its potential anti-inflammatory role in hepatocellular carcinoma therapy.

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Soydaş et al. (2026) studied this question.

synapsesocial.com/papers/6a8d4a26e8bd2413309bc06b https://doi.org/10.17944/interdiscip.1833817

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Association of AP-1/c-Jun with IL-6 and IL-8 expression in hepatocellular carcinoma: attenuating effects of metformin in vitro

Key Points

No abstract yet

Implication

Discussion

Cite This Study

Association of AP-1/c-Jun with IL-6 and IL-8 expression in hepatocellular carcinoma: attenuating effects of metformin in vitro

Key Points

No abstract yet

Implication

Discussion

Cite This Study

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