Experimental stability study demonstrates superior redispersibility and physical stability for Avicel RC-591 and CMC-Na in sucralfate suspensions, highlighting their viability over xanthan gum.
Sucralfate is a medicine for peptic ulcers that is practically insoluble in water and might to be developed into a suspension. The choice of suspending agents is essential for formula development. This study aimed to determine the physical characteristics and physical stability of xanthan gum, CMC-Na, and Avicel RC-591 in a sucralfate suspension by conducting a characterization and stability study and analyzing the formulations. Suspensions were prepared with 0.3% w/v xanthan gum (XG), 1% w/v CMC-Na (SCMC), and 1% w/v Avicel RC-591 (ARC) and then evaluated for physical appearance, pH, density, viscosity, sedimentation, and redispersibility in a six-month stability study conducted under various storage conditions. The pH results ranged between 5.113 ± 0.001 and 4.622 ± 0.033 (p > 0.05). The density of the SCMC formula (1.1459 ± 0.0003) is greater than the density of the ARC formula (1.1396 ± 0.0002) and XG (1.1162 ± 0.0002), but statistically, the three formulas are not significantly different (p > 0.05). The viscosity of XG is greater than SCMC and ARC. The formulas indicated that XG had greater sedimentation than SCMC and ARC (p > 0.05). The redispersibility of all formulations is ARC > SCMC > XG. In conclusion, ARC and SCMC exhibit acceptable suspension characteristics and robust physical stability. Conversely, formulations utilizing XG fail to meet the required quality standards for sucralfate suspensions regarding redispersibility.
No takes yet. Share an insight, caveat, or question.
Hutabarat et al. (2026) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: