Zoxazolamine — A Potent Uricosuric Agent

ZOXAZOLAMINE¶ has been widely used during the past two years for the purpose of decreasing spasm of skeletal muscle, presumably via a depressant effect upon polysynaptic pathways in the central nervous system. Occasional side effects, such as drowsiness, lightheadedness, dizziness, abdominal discomfort, vomiting, headache and transient blotching of the skin, are transitory, and the most troublesome, the gastrointestinal symptoms, are usually avoided by administration of the drug with food. No changes in blood pressure, respiration, blood count, urinalysis tests or of hepatic and renal function were noted in the clinical study by Amols.1 Serious toxicity is apparently absent, and the . . .