Key result
Patients with chronic obstructive pulmonary disease exhibited significantly reduced right ventricular free wall longitudinal strain (16.53% vs 21.39%, p<0.001) compared to healthy controls.
Why the study?
Cardiovascular disease is a leading cause of mortality in COPD, making early identification of cardiac abnormalities crucial, but the role of STE in assessing ventricular and atrial function in COPD patients remains under-researched.
Does COPD alter right ventricular, left ventricular, and left atrial strain measured by speckle tracking echocardiography compared to healthy controls?
Cross-Sectional (n=69)
Single-blind
No
Does COPD alter right ventricular, left ventricular, and left atrial strain measured by speckle tracking echocardiography compared to healthy controls?
Absolute Event Rate: 16.53% vs 21.39%
p-value: p=<0.001
Speckle tracking echocardiography identifies subclinical right and left ventricular dysfunction in COPD patients before significant alterations in left ventricular ejection fraction occur.
Evidence Level: Level 4, Cross-Sectional Study.
OBJECTIVES: Cardiovascular disease is a prevalent comorbidity and leading cause of mortality in chronic obstructive pulmonary disease (COPD) patients. Early identification of cardiac abnormalities in COPD patients is crucial. Speckle tracking echocardiography (STE) is practical for assessing ventricular and atrial function, but its role in COPD patients is under-researched. This study aimed to examine right ventricular (RV), left ventricular (LV) and left atrial (LA) strain in COPD patients via STE. METHODS: A cross-sectional study was conducted with two groups: COPD patients diagnosed per the 2017 Global Initiative for Chronic Obstructive Lung Disease criteria and healthy controls. All the participants underwent STE to evaluate the RV, LV, and LA strains. RESULTS: RV strain indices (RV free wall longitudinal strain (RVFWSL) and RV 4-chamber longitudinal strain (RV4CSL)) were significantly lower in the COPD group (16.53±5.89% and 14.65±4.53%, respectively) than in the control group (21.39±7.78% and 18.34±6.38%, respectively) (p<0.001). LV global longitudinal strain was also lower in the COPD group (18.45% (17.16-19.51)) than in the control group (19.50% (18.63-21.46), p=0.018). No significant differences were found in LA strain indices (LA reservoir strain, LA conduit strain or LA contractile strain) between the two groups. Furthermore, RVFWSL and RV4CSL were significantly greater in the group with a modified Medical Research Council score <2 (p<0.05). CONCLUSION: Compared with healthy controls, COPD patients presented reduced RV and LV strain, with no significant differences in LA strain indices.
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Dang et al. (2025) conducted a cross-sectional in Chronic obstructive pulmonary disease (n=69). Chronic obstructive pulmonary disease vs. Healthy controls was evaluated on Right ventricular free wall longitudinal strain (RVFWSL) (p=<0.001). Patients with chronic obstructive pulmonary disease exhibited significantly reduced right ventricular free wall longitudinal strain (16.53% vs 21.39%, p<0.001) compared to healthy controls.
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