Synthetic Glycopeptides from the E‐Selectin Ligand 1 with Varied Sialyl Lewisx Structure as Cell‐Adhesion Inhibitors of E‐Selectin

Cooperation is key: Peptide and saccharide portions cooperate in sialyl Lewisx glycopeptides and their mimetics in the fucose and sialic acid parts (see formula), resulting in up to greater than 100-fold stronger binding to E-selectin. The synthesis provided sialyl Lewisx amino acids in a form sufficiently acid-stable for application in automated solid-phase syntheses of glycopeptides based on acid-sensitive linkers.