What is the clinical evidence from this study?

Study design: Editorial. Population: Spinal cord injury and ventricular arrhythmias. Intervention: T5 spinal cord transection vs. Intact rats. Primary outcome: Cardiac sympathetic preganglionic neuronal (SPN) arborization and left ventricular NGF content.

August 12, 2010AJP Regulatory Integrative and Comparative Physiology

Editorial Focus: role for neural growth factor in autonomically driven arrhythmogenesis? Focus on: “Structural neuroplasticity following T5 spinal cord transection: increased cardiac sympathetic innervation density and SPN arborization”

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Key result

Midthoracic level 5 spinal cord transection in rats significantly increased cardiac sympathetic preganglionic neuronal arborization, left ventricular NGF content, and sympathetic density.

Population

Rats with midthoracic level 5 (T5) spinal cord transection (preclinical model discussed in the editorial)

Comparison

Midthoracic level 5 (T5) spinal cord transection vs Intact rats

Design

Editorial

Authors

JMJulia A. MoffittStephens College

Discussion

Member takes

Implication

This editorial highlights evidence that spinal cord injury induces sympathetic hyperinnervation of the heart via neural growth factor, providing a potential mechanism for autonomically driven arrhythmogenesis.

Structured PICO

Population

Rats with midthoracic level 5 (T5) spinal cord transection (preclinical model discussed in the editorial)

Exposure

Midthoracic level 5 (T5) spinal cord transection

Comparator

Intact rats

Outcome

Cardiac sympathetic preganglionic neuronal (SPN) arborization, left ventricular neural growth factor (NGF) content, and left ventricular sympathetic densitysurrogate

Limitations

Only evaluated changes within the left ventricle, providing a snapshot of neuroplastic changes
Did not block NGF expression to definitively prove its mechanistic role
Source of NGF remains unidentified
Only evaluated changes within the left ventricle, providing a limited snapshot of neuroplastic changes
Did not block NGF expression to determine a definitive mechanistic role
Source of NGF within the process remains unidentified

Cite This Study

Julia A. Moffitt (2010) conducted an editorial in Spinal cord injury and ventricular arrhythmias. T5 spinal cord transection vs. Intact rats was evaluated on Cardiac sympathetic preganglionic neuronal (SPN) arborization and left ventricular NGF content. Midthoracic level 5 spinal cord transection in rats significantly increased cardiac sympathetic preganglionic neuronal arborization, left ventricular NGF content, and sympathetic density.

synapsesocial.com/papers/6a8d70e309d0835cef7fec78 https://doi.org/10.1152/ajpregu.00524.2010

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Editorial Focus: role for neural growth factor in autonomically driven arrhythmogenesis? Focus on: “Structural neuroplasticity following T5 spinal cord transection: increased cardiac sympathetic innervation density and SPN arborization”

Discussion

Member takes

Implication

Structured PICO

Limitations

Cite This Study

Editorial Focus: role for neural growth factor in autonomically driven arrhythmogenesis? Focus on: “Structural neuroplasticity following T5 spinal cord transection: increased cardiac sympathetic innervation density and SPN arborization”

Discussion

Member takes

Implication

Structured PICO

Limitations

Cite This Study

Also Consider

Also Consider