Why the study?
Does T5 spinal cord transection increase left ventricular NGF content, sympathetic innervation density, and cardiac SPN arborization in rats?
Population
Intact and paraplegic (9 wk posttransection) rats
Comparison
T5 spinal cord transection (T5X) vs Intact rats
Design
Preclinical
Follow-up
9 weeks
Authors
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May underlie post-SCI cardiovascular dysregulation in rats; leaves open translation to human sympathetic remodeling.
Does T5 spinal cord transection increase left ventricular NGF content, sympathetic innervation density, and cardiac SPN arborization in rats?
T5 spinal cord transection in rats leads to structural neuroplastic modifications, including increased cardiac sympathetic innervation and NGF content, which may explain abnormal cardiovascular control post-spinal cord injury.
Lujan et al. (2010) studied this question.
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