Key result
T5 spinal cord transection in rats impaired left ventricular function and enhanced sympathetic support of heart rate and contractility, accompanied by increased stellate ganglia NGF content and structural neuroplasticity.
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May inform mechanisms of post-SCI cardiac dysfunction; hypothesis-generating for human translation and leaves clinical relevance open.
p-value: p=<0.05
Lujan et al. (2012) studied Midthoracic spinal cord injury (n=52). T5 spinal cord transection vs. Sham surgery was evaluated on Left ventricular function (dP/dt), sympathetic support, stellate ganglia NGF content, and dendritic arborization (p=<0.05). T5 spinal cord transection in rats impaired left ventricular function and enhanced sympathetic support of heart rate and contractility, accompanied by increased stellate ganglia NGF content and structural neuroplasticity.
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