Why the study?
Does high thoracic spinal cord injury cause load-independent systolic cardiac dysfunction in a Wistar rodent model?
Population
Wistar rodent model
Comparison
High thoracic contusion spinal cord injury vs Control (uninjured)
Design
Preclinical
Follow-up
5 weeks
Authors
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Suggests high thoracic spinal cord injury may directly drive intrinsic myocardial dysfunction; leaves open whether targeted sympathom.
Does high thoracic spinal cord injury cause load-independent systolic cardiac dysfunction in a Wistar rodent model?
Spinal cord injury induces load-independent systolic cardiac dysfunction and cardiomyocyte atrophy, likely driven by the loss of descending sympatho-excitatory control.
Squair et al. (2017) studied this question.
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