Why the study?
Complications after spinal cord injury stem from unregulated reflexes below the lesion, but the long-term impact of spinal cord injury on neurovascular transmission is poorly understood.
Population
Rats with long-term paraplegia (T2-3) and tetraplegia (C6-7)
Comparison
T2-3 and C6-7 spinal cord injury vs sham or intact controls
Design
Animal experimental study
Authors
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Enhanced neurovascular transmission after chronic SCI in rats; leaves open relevance to human autonomic complications.
Spinal cord injury increases purinergic neurotransmission to mesenteric arteries via enhanced ATP release, suggesting a potential therapeutic target for maintaining stable blood pressure in SCI patients.
Sangsiri et al. (2019) studied this question.
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