Key result
Spinal cord transection in rats potentiated nerve-evoked contractions in saphenous arteries (caudal to lesion) but not in median arteries (rostral to lesion) at 2 and 8 weeks.
Population
Rats evaluated 2 and 8 weeks after transection of the T4 spinal cord, and sham-operated rats
Comparison
T4 spinal cord transection (SCI) vs Sham operation
Design
Preclinical
Follow-up
2 and 8 weeks
Authors
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May contribute to autonomic dysreflexia after spinal cord injury; leaves open translation to humans.
Spinal cord injury potentiates sympathetic neurovascular transmission in arteries caudal to the lesion, likely due to increased neurotransmitter release, which may contribute to autonomic dysreflexia.
Rummery et al. (2010) studied Spinal cord injury. T4 spinal cord transection vs. Sham-operated rats was evaluated on Nerve-evoked contractions of median and saphenous arteries. Spinal cord transection in rats potentiated nerve-evoked contractions in saphenous arteries (caudal to lesion) but not in median arteries (rostral to lesion) at 2 and 8 weeks.
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