Population
Animal model of high spinal cord injury 6 weeks post-injury, and intact animals
Comparison
Intravenous injections of alpha-adrenergic… vs Intact animals receiving the same interventions
Design
Preclinical
Follow-up
6 weeks post-injury
Authors
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May warrant caution with phenylephrine post-SCI; hypothesis-generating for peripheral vascular adaptations in humans.
High spinal cord injury leads to widespread peripheral changes producing prolonged vasoconstriction in response to phenylephrine both above and below the injury level, likely due to reduced neuronal reuptake.
Laird et al. (2007) studied this question.
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