What question did this study set out to answer?

Characterize renal involvement and tubular functional abnormalities in patients diagnosed with primary Sjögren's syndrome presenting with extraglandular manifestations.

January 1, 1989Scandinavian Journal of Rheumatology

Renal Involvement in Patients with Primary Sjögren's Syndrome

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Characterize renal involvement and tubular functional abnormalities in patients diagnosed with primary Sjögren's syndrome presenting with extraglandular manifestations.
Followed 65 patients with primary Sjögren's syndrome (63 women, 2 men) over a mean period of 6.2 years, monitoring renal biochemistry and urinalysis.
Administered oral ammonium chloride loading tests (0.1 g/kg body weight) to 10 acidemic patients and 15 controls without renal involvement to assess urinary acidification.
Performed intravenous bicarbonate loading tests (0.125 g/kg over 2 hours) to determine the specific subtype of renal tubular acidosis.
Identified chronic tubulointerstitial nephritis presenting as renal tubular acidosis and hyposthenuria as the predominant renal lesion, while glomerulonephritis occurred rarely.
Determined urinary acidification capacity and acid-base excretion dynamics via serial measurement of urinary pH, ammonia, and titratable acidity following provocation tests.

Authors

GPG PokornyUniversity of Szeged SSS. SonkodiUniversity of Szeged BIBéla IványiUniversity of Szeged

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Implication

Cohort study reveals kidney tubular dysfunction in primary Sjögren's syndrome, highlighting chronic tubulointerstitial nephritis and acid-base disturbances.

Cite This Study

Pokorny et al. (1989) studied this question.

synapsesocial.com/papers/6a8d76dd9a08a4eedd7fe90f https://doi.org/10.3109/03009748909099934

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Implication

Cohort study reveals kidney tubular dysfunction in primary Sjögren's syndrome, highlighting chronic tubulointerstitial nephritis and acid-base disturbances.

Renal Involvement in Patients with Primary Sjögren's Syndrome

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Discussion

Implication

Cite This Study

Renal Involvement in Patients with Primary Sjögren's Syndrome

Key Points

Discussion

Implication

Cite This Study

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