Key result
Higher ankle dorsiflexion and plantar flexion strengths were significantly associated with a lower likelihood of high ischemia severity in patients with peripheral arterial disease (OR 0.82 and 0.79, respectively).
Why the study?
The role of ankle muscle strength and endurance in assessing ischemia severity in patients with peripheral arterial disease remains underexplored.
Cross-Sectional (n=53)
No
Odds Ratio: 0.82 (95% CI 0.74–0.91)
p-value: p=<0.001
Ankle dorsiflexion and plantar flexion strength assessments correlate with ischemia severity and may serve as predictive markers for vascular recovery in PAD patients.
Suggests ankle muscle strength assessment may serve as a non-invasive marker of ischemia severity in PAD.
BACKGROUND: Peripheral Arterial Disease (PAD) is a global health concern, particularly among aging populations. While previous studies have examined various aspects of PAD, the role of ankle muscle strength and endurance in assessing ischemia severity remains underexplored. This study investigates the relationship between ankle dorsiflexion and plantar flexion strength and ischemia severity in PAD patients. METHODS: This cross-sectional observational study included 53 PAD patients with chronic limb ischemia confirmed via angiography. Mean age was 64.5 years, and the majority were male. Ankle muscle strength was measured using a custom-designed hand-held dynamometer, which underwent internal validation and reliability testing before implementation. Spearman's correlation and multiple regression models assessed the association between muscle function and ischemia severity. RESULTS: A significant positive correlation was found between dorsiflexion/plantar flexion strength and ischemia severity one-month post-intervention (Spearman's rho = 0.35, P = 0.015; Spearman's rho = 0.40, P = 0.010). Pre-intervention assessments established a baseline correlation, allowing evaluation of ischemia progression and its impact on muscle function. CONCLUSION: Our data showed that ankle strength assessments may serve as predictive markers for ischemia severity in PAD patients. Implementing these measurements in clinical practice could enhance treatment optimization and patient outcomes.
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Hassabi et al. (2025) conducted a cross-sectional in Peripheral Arterial Disease (PAD) with chronic limb ischemia (n=53). Ankle muscle strength (dorsiflexion and plantar flexion) was evaluated on Association between dorsiflexion strength and ischemia severity (OR 0.82, 95% CI 0.74-0.91, p=<0.001). Higher ankle dorsiflexion and plantar flexion strengths were significantly associated with a lower likelihood of high ischemia severity in patients with peripheral arterial disease (OR 0.82 and 0.79, respectively).
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