Key result
A supine bicycle ergometry protocol yielded highly reproducible heart rate responses, permitting sensitive comparison of beta 1-adrenoceptor antagonism across dose and time.
Population
Healthy subjects
Design
Other
Authors
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May facilitate sensitive beta-blocker pharmacodynamic studies; leaves open clinical adoption pending validation.
A standardized supine bicycle ergometry protocol provides highly reproducible heart rate responses, enabling sensitive evaluation of beta 1-adrenoceptor antagonist efficacy.
Mey et al. (1994) studied Healthy subjects. Supine bicycle ergometry protocol was evaluated on Ergometric HR-responses. A supine bicycle ergometry protocol yielded highly reproducible heart rate responses, permitting sensitive comparison of beta 1-adrenoceptor antagonism across dose and time.
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