Why the study?
What are the dose-effect and pharmacokinetic-pharmacodynamic relationships of various doses of carvedilol compared to placebo and propranolol in healthy males?
Population
12 healthy male subjects
Comparison
Single peroral dose of 12.5, 25, 50, or 100 mg… vs Single peroral dose of 40 mg propranolol or…
Design
Other
Follow-up
22 hours after dosing
Authors
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Supports simple beta-1 blockade relationships for carvedilol in volunteers; leaves open translation to patients.
What are the dose-effect and pharmacokinetic-pharmacodynamic relationships of various doses of carvedilol compared to placebo and propranolol in healthy males?
The complex kinetics of carvedilol do not preclude relatively simple and straight-forward dose-effect and kinetic-dynamic relationships for its beta-1 blocking effects.
Mey et al. (1994) studied this question.
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