Key result
Single oral doses of metoprolol decreased heart rate during exercise (-21% to -24%) slightly more than carvedilol (-16% to -18%), whereas carvedilol had weak effects on resting heart rate.
Why the study?
Do single oral doses of metoprolol and carvedilol reduce heart rate and blood pressure differently at rest and during exercise in healthy male volunteers?
Population
12 healthy male volunteers
Comparison
Single oral doses of metoprolol or carvedilol vs Placebo
Design
RCT, randomised, cross-over, double-blind
Follow-up
2 hours post-dose (plus 10 min exercise and 15 min recovery)
Authors
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Clinicians should weigh resting HR differences when selecting beta-blockers; extends carvedilol-metoprolol differentiation from healthy volunteers to potential patient use.
RCT (n=12)
Double-blind
Cross-over
Do single oral doses of metoprolol and carvedilol reduce heart rate and blood pressure differently at rest and during exercise in healthy male volunteers?
In healthy subjects, carvedilol provides weaker resting heart rate reduction compared to metoprolol, likely due to reflex sympathetic activation from its alpha-blocking properties, though both effectively reduce heart rate during exercise.
Stoschitzky et al. (2001) conducted an RCT in Healthy (n=12). Metoprolol and Carvedilol vs. Placebo was evaluated on Heart rate and blood pressure at rest, after 10 min of exercise, and after 15 min of recovery. Single oral doses of metoprolol decreased heart rate during exercise (-21% to -24%) slightly more than carvedilol (-16% to -18%), whereas carvedilol had weak effects on resting heart rate.
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