Key result
Tenectaplase was associated with similar in-hospital mortality compared to streptokinase (8.9% vs 5.3%, p=0.322) in STEMI patients, but resulted in less frequent hypotension.
Why the study?
Does tenectaplase reduce in-hospital mortality compared to streptokinase in Chinese STEMI patients?
Observational (n=196)
No
Does tenectaplase reduce in-hospital mortality compared to streptokinase in Chinese STEMI patients?
Tenectaplase is comparable in safety to streptokinase for STEMI treatment, offering shorter door-to-needle times and a lower risk of hypotension.
May reduce hypotension versus streptokinase in STEMI without mortality increase; hypothesis-generating in Chinese patients and requires randomized confirmation.
Objective Data were lacking in comparing tenectaplase (TNK) and streptokinase (SK) in treating Chinese ST elevation myocardial infarction (STEMI) patients. We sought to compare these 2 types of thrombolytics in our locality. Methods We analysed 196 STEMI patients who received either TNK or SK in our hospital from 2007 to 2011. We compared the mortality and other outcomes of these 2 groups of patients. Results In‐hospital mortality has no significant difference between the TNK and the SK groups (8.9% vs 5.3%, p=0.322). Door‐to‐needle time was shorter in the TNK group (31±10 vs 25±7, p<0.001). Hypotension after drug administration was more common in the SK group than in the TNK group (21.1% vs. 3.0%, p<0.001). Conclusion TNK is at least as safe as SK in treating STEMI patients, with the advantage of shorter door‐to‐needle time and less frequent hypotensive effect. (Hong Kong j.emerg.med. 2013;20:359‐363)
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Chau et al. (2013) conducted an observational in ST elevation myocardial infarction (STEMI) (n=196). Tenectaplase vs. Streptokinase was evaluated on In-hospital mortality (p=0.322). Tenectaplase was associated with similar in-hospital mortality compared to streptokinase (8.9% vs 5.3%, p=0.322) in STEMI patients, but resulted in less frequent hypotension.
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