Key result
The cardiovascular functional avatar, a personalized lumped parameter model tuned exclusively with non-invasive 4D Flow MRI and cuff pressure data, accurately reproduced in vivo flow waveforms and systolic blood pressures in healthy subjects.
Why the study?
Does a personalized cardiovascular lumped parameter model using non-invasive measurements accurately reproduce in vivo pressures and flows in healthy subjects?
Does a personalized cardiovascular lumped parameter model using non-invasive measurements accurately reproduce in vivo pressures and flows in healthy subjects?
A personalized cardiovascular lumped parameter model using exclusively non-invasive 4D Flow MRI and cuff pressure can accurately reproduce subject-specific hemodynamics in healthy volunteers.
Demonstrates the feasibility of non-invasive hemodynamic profiling using 4D flow MRI; leaves open whether.
Lumped parameter models of the cardiovascular system have the potential to assist researchers and clinicians to better understand cardiovascular function. The value of such models increases when they are subject specific. However, most approaches to personalize lumped parameter models have thus far required invasive measurements or fall short of being subject specific due to a lack of the necessary clinical data. Here, we propose an approach to personalize parameters in a model of the heart and the systemic circulation using exclusively non-invasive measurements. The personalized model is created using flow data from four-dimensional magnetic resonance imaging and cuff pressure measurements in the brachial artery. We term this personalized model the cardiovascular avatar. In our proof-of-concept study, we evaluated the capability of the avatar to reproduce pressures and flows in a group of eight healthy subjects. Both quantitatively and qualitatively, the model-based results agreed well with the pressure and flow measurements obtained in vivo for each subject. This non-invasive and personalized approach can synthesize medical data into clinically relevant indicators of cardiovascular function, and estimate hemodynamic variables that cannot be assessed directly from clinical measurements.
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Casas et al. (2017) studied Healthy (n=8). Cardiovascular functional avatar (personalized lumped parameter model) vs. In vivo measurements was evaluated on Agreement between model-based and measured volumetric flow waveforms and pressures. The cardiovascular functional avatar, a personalized lumped parameter model tuned exclusively with non-invasive 4D Flow MRI and cuff pressure data, accurately reproduced in vivo flow waveforms and systolic blood pressures in healthy subjects.
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