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This paper describes the preparation of 1,2,4‐oxadiazoles by condensation of an aliphatic nitrile oxide with a nitrile. The nitrile is formed «in situ» by treating a nitroalkane with an isocyanate in the presence of a tertiary base. The nitrile must be activated by an electron withdrawing substituent.
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F. Eloy (1964) studied this question.
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