Key result
This letter to the editor highlights that the association between pericoronary adipose tissue attenuation and major adverse cardiac events requires cautious interpretation due to potential confounding.
This editorial highlights the need for caution and more granularity regarding confounding features in studies assessing pericoronary adipose tissue attenuation and its association with major adverse cardiac events.
We read with interest the recent study by Sagris et al.1 and congratulate the authors for the first systematic review and meta-analysis examining pericoronary adipose tissue (PCAT) and associations with major adverse cardiac events (MACE). Nonetheless, this field is perhaps more nuanced and immature than might be apparent from this study. The work from the authors is commendable, but there remain important limitations and caution must be taken with the current results. Subsequent systematic reviews might need to provide more granularity regarding potential confounding features. No new data were generated or analysed in support of this research.
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Tan et al. (2023) conducted a letter in Major adverse cardiac events (MACE). Pericoronary adipose tissue (PCAT) attenuation was evaluated. This letter to the editor highlights that the association between pericoronary adipose tissue attenuation and major adverse cardiac events requires cautious interpretation due to potential confounding.
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