Key result
Proteomics plays a critical role in understanding cardiovascular systems, informing investigations into organelles, signaling complexes, and cardiac phenotype in myocardial injury and protection.
This review highlights the critical role of proteomics in understanding cardiovascular systems, specifically regarding myocardial injury, protection, and cardiac cell function.
Supports proteomic research on myocardial injury; leaves open clinical translation pending prospective validation.
Cardiovascular disease is the leading cause of death and disability in the developed world. To design novel therapeutic strategies to treat and prevent this disease, better understanding of cardiac cell function is necessary. In addition to (and, indeed, in combination with) genetics, physiology and molecular biology, proteomics plays a critical role in our understanding of cardiovascular systems at multiple scales. The purpose of this review is to examine recent developments in the field of myocardial injury and protection, examining how proteomics has informed investigations into organelles, signaling complexes, and cardiac phenotype.
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MacLellan et al. (2008) conducted a review in Cardiovascular disease. Proteomics was evaluated. Proteomics plays a critical role in understanding cardiovascular systems, informing investigations into organelles, signaling complexes, and cardiac phenotype in myocardial injury and protection.
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