Key result
Arsenite treatment in adult rat ventricular myocytes caused a 16-fold increase in p38 MAPK phosphorylation and decreased isometric tension without changing Ca2+ sensitivity.
Population
Adult rat ventricular myocytes
Comparison
1 mM arsenite for 30 min vs Untreated myocytes or myocytes treated with…
Design
Preclinical
Follow-up
30 minutes
Authors
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Acute p38 MAPK activation may impair rat myocyte force; leaves open in vivo relevance and human translation.
Acute p38 MAPK activation decreases myocardial force development in adult rat ventricular myocytes.
Chen et al. (2003) studied this question. Arsenite was evaluated on p38 MAPK phosphorylation and isometric tension. Arsenite treatment in adult rat ventricular myocytes caused a 16-fold increase in p38 MAPK phosphorylation and decreased isometric tension without changing Ca2+ sensitivity.
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