Key result
Preischemic treatment with U-50488H or phenylephrine + propranolol improved postischemic LVDP recovery by 25-30% and lowered actomyosin Mg(2+)-ATPase by 20% compared with control rat hearts.
Population
Isolated rat hearts and single ventricular myocytes
Comparison
kappa-opioid receptor agonist U-50488H or… vs Control hearts
Design
Preclinical
Authors
Loading...
Hypothesis-generating for receptor-mediated preconditioning in ischemia; leaves open translation to human myocardium.
Kappa-opioid and alpha-adrenergic receptor stimulation may confer cardioprotection during ischemia by decreasing actin-myosin cycling rate and conserving ATP.
Pyle et al. (2000) studied Ischemic damage. U-50488H or phenylephrine + propranolol vs. Control hearts was evaluated on Postischemic left ventricular developed pressure (LVDP) recovery and myofibrillar Ca(2+)-dependent actomyosin Mg(2+)-ATPase. Preischemic treatment with U-50488H or phenylephrine + propranolol improved postischemic LVDP recovery by 25-30% and lowered actomyosin Mg(2+)-ATPase by 20% compared with control rat hearts.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: