Key result
Morphine or BW373U86 administered before ischemia reduced cell death in chick cardiomyocytes (31% and 28%, respectively, vs. 53% in controls; P<0.05).
Why the study?
Does morphine or delta-opioid receptor agonist reduce cell death in chick cardiomyocytes subjected to ischemia-reperfusion?
Does morphine or delta-opioid receptor agonist reduce cell death in chick cardiomyocytes subjected to ischemia-reperfusion?
Absolute Event Rate: 31% vs 53%
p-value: p=< 0.05
Stimulation of delta1-opioid receptors generates oxygen radicals via mitochondrial KATP channels, which attenuates oxidant stress and cell death in cardiomyocytes during ischemia-reperfusion.
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Does not support clinical use of delta-opioid agonists for cardioprotection; leaves open translation from chick cardiomyocyte data to human trials.
McPherson et al. (2001) studied Myocardial ischemia-reperfusion injury. Morphine or BW373U86 vs. Controls was evaluated on Cell death (p=< 0.05). Morphine or BW373U86 administered before ischemia reduced cell death in chick cardiomyocytes (31% and 28%, respectively, vs. 53% in controls; P<0.05).
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