Why the study?
Does postconditioning reduce infarct size in rat hearts subjected to ischemia and reperfusion?
Population
Rat hearts and isolated cardiomyocytes subjected to 30 min of ischemia and 2 h of reperfusion
Comparison
Postconditioning or morphine vs Ischemia/reperfusion without postconditioning
Design
Preclinical
Follow-up
2 hours of reperfusion
Authors
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Rat postconditioning data should not alter clinical practice; leaves open translation of delta-opioid and mPTP mechanisms to human reperfusion injury.
Does postconditioning reduce infarct size in rat hearts subjected to ischemia and reperfusion?
Postconditioning protects the heart from reperfusion injury by targeting the mitochondrial permeability transition pore through activation of delta-opioid receptors and the NO-cGMP-PKG pathway.
Jang et al. (2008) studied this question.
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