October 29, 2009Acta Anaesthesiologica Scandinavica

Remifentanil post‐conditioning attenuates cardiac ischemia–reperfusion injury via κ or δ opioid receptor activation

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Why the study?

Does remifentanil post-conditioning reduce myocardial infarct size in a rat model of ischemia-reperfusion injury?

Population

Rat heart model of ischemia and reperfusion injury (open-chest and isolated heart models)

Comparison

Remifentanil post-conditioning with or without… vs Control group and ischemic post-conditioning

Design

Preclinical

Authors

GWGordon Tin Chun WongUniversity of Hong Kong RLR. LiChengdu Military General Hospital LJLingling JiangJiangsu University

Discussion

Member takes

Implication

Hypothesis-generating for remifentanil post-conditioning in rat ischemia-reperfusion; leaves open translation to human cardioprotection.

Structured PICO

Does remifentanil post-conditioning reduce myocardial infarct size in a rat model of ischemia-reperfusion injury?

Population

Rat heart model of ischemia and reperfusion injury (open-chest and isolated heart models)

Intervention

Remifentanil post-conditioning (5-min infusion at 1, 5, 10 or 20 microg/kg/min) with or without specific opioid receptor antagonists (nor-binaltorphimine, naltrindole, CTOP)

Comparator

Control group and ischemic post-conditioning (three cycles of 10 s reperfusion interspersed with 10 s ischemia)

Outcome

Myocardial infarct sizesurrogate

Remifentanil post-conditioning protects the rat heart from ischemia-reperfusion injury to a similar extent as ischemic post-conditioning, mediated via kappa and delta opioid receptor activation.

Cite This Study

Wong et al. (2009) studied this question.

synapsesocial.com/papers/6a853d359df997f4bbd6a326 https://doi.org/10.1111/j.1399-6576.2009.02145.x

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Remifentanil post‐conditioning attenuates cardiac ischemia–reperfusion injury via κ or δ opioid receptor activation

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Remifentanil post‐conditioning attenuates cardiac ischemia–reperfusion injury via κ or δ opioid receptor activation

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider