Key result
Remifentanil significantly reduced myocardial infarct size to 18.8-20.1% compared to 43.6% in the control group, regardless of the timing of administration.
Why the study?
Does remifentanil reduce myocardial infarct size and apoptosis in an ischemia-reperfused rat heart model?
Does remifentanil reduce myocardial infarct size and apoptosis in an ischemia-reperfused rat heart model?
Answers are grounded in this paper and cite their sources.
Remifentanil confers myocardial protection against ischemia-reperfusion injury in rats regardless of administration timing, mediated by anti-apoptotic pathways and preserved sarcoplasmic reticulum gene expression.
Remifentanil is a commonly used opioid in anesthesia with cardioprotective effect in ischemia-reperfused (I/R) heart. We evaluated the influence of remifentanil on myocardial infarct size and expressions of proteins involved in apoptosis in I/R rat heart following various time protocols of remifentanil administration. Artificially ventilated anesthetized Sprague-Dawley rats were subjected to a 30 min of left anterior descending coronary artery occlusion followed by 2 h of reperfusion. Rats were randomly assigned to one of five groups; Sham, I/R only, remifentanil preconditioning, postconditioning and continuous infusion group. Myocardial infarct size, the phosphorylation of ERK1/2, Bcl2, Bax and cytochrome c and the expression of genes influencing Ca2+ homeostasis were assessed. In remifentanil-administered rat hearts, regardless of the timing and duration of administration, infarct size was consistently reduced compared to I/R only rats. Remifentanil improved expression of ERK1/2 and anti-apoptotic protein Bcl2, and expression of sarcoplasmic reticulum genes which were significantly reduced in the I/R rats only. Remifentanil reduced expression of pro-apoptotic protein, Bax and cytochrome c. These suggested that remifentanil produced cardioprotective effect by preserving the expression of proteins involved in anti-apoptotic pathways, and the expression of sarcoplasmic reticulum genes in I/R rat heart, regardless of the timing of administration.
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Kim et al. (2010) studied Myocardial ischemia-reperfusion injury (n=34). Remifentanil vs. Ischemia/reperfusion without remifentanil was evaluated on Myocardial infarct size as a percentage of the left ventricle (p=<0.05). Remifentanil significantly reduced myocardial infarct size to 18.8-20.1% compared to 43.6% in the control group, regardless of the timing of administration.
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