Why the study?
Does remifentanil preconditioning reduce infarct size in isolated rat hearts via specific opioid receptors?
Population
Isolated hearts from male Sprague-Dawley rats weighing 190-210 g subjected to 30 min of ischemia and 2 h of…
Comparison
Remifentanil preconditioning via three cycles of… vs Control.
Design
Preclinical
Follow-up
2 hours of reperfusion
Authors
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May support delta/kappa-opioid receptor-mediated cardioprotection in rat hearts; leaves open translation to human perioperative or ischemic settings.
Does remifentanil preconditioning reduce infarct size in isolated rat hearts via specific opioid receptors?
Remifentanil preconditioning confers cardioprotection in isolated rat hearts through cardiac delta- and kappa-opioid receptors, involving protein kinase C and mitochondrial KATP channels.
Zhang et al. (2005) studied this question.
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