Remifentanil Preconditioning Reduces Postischemic Myocardial Infarction and Improves Left Ventricular Performance via Activation of the Janus Activated Kinase-2/Signal Transducers and Activators of Transcription-3 Signal Pathway and Subsequent Inhibition of Glycogen Synthase Kinase-3β in Rats

Shigang Qiao; Xiao Wen Mao; Yan Wang; Shaoqing Lei; Yanan Liu; Tingting Wang; Gordon Tin Chun Wong; Chi‐Wai Cheung; Zhengyuan Xia; Michael G. Irwin

doi:10.1097/ccm.0000000000001350

October 15, 2015Critical Care Medicine

Remifentanil Preconditioning Reduces Postischemic Myocardial Infarction and Improves Left Ventricular Performance via Activation of the Janus Activated Kinase-2/Signal Transducers and Activators of Transcription-3 Signal Pathway and Subsequent Inhibition of Glycogen Synthase Kinase-3β in Rats

View Full Paper

Ask AI

Bookmark

Share

Why the study?

Does remifentanil preconditioning reduce myocardial ischemia reperfusion injury via JAK2/STAT3 and GSK-3β signaling in rat models?

Structured PICO

Does remifentanil preconditioning reduce myocardial ischemia reperfusion injury via JAK2/STAT3 and GSK-3β signaling in rat models?

P

Population

Male Sprague-Dawley rats (n = 6 per group), isolated rat hearts (Langendorff perfused), isolated primary rat cardiomyocytes, and H9C2 cells subjected to myocardial ischemia reperfusion injury or hypoxia/reoxygenation.

I

Intervention

Remifentanil preconditioning (in vivo: 6 μg/kg/min; isolated hearts: 100 ng/mL; cells: 2.5 μM) alone or in combination with JAK2 inhibitor AG490, PI3K inhibitor wortmannin, glycogen synthase kinase-3β inhibitor SB216763, or specific synthetic RNA for gene knockdown.

C

Comparator

Sham operation, myocardial ischemia reperfusion injury alone, or hypoxia/reoxygenation alone without remifentanil preconditioning.

O

Outcome

Postischemic myocardial infarction size and hemodynamic dysfunction.surrogate

Remifentanil preconditioning protects against myocardial ischemia-reperfusion injury primarily via the JAK2/STAT3 signaling pathway and subsequent inhibition of GSK-3β, independent of PI3K/Akt activation.

Implication

Hypothesis-generating for remifentanil preconditioning in ischemia-reperfusion injury; clinical translation and pathway validation require human studies.

Abstract

No abstract yet. The journal hasn't published one we can show.

Discussion

No takes yet. Share an insight, caveat, or question.

Cite This Study

Qiao et al. (2015) studied this question.

synapsesocial.com/papers/6a827873f337522b6774bafb https://doi.org/10.1097/ccm.0000000000001350

View Full Paper

Ask AI

Bookmark

Share

Remifentanil Preconditioning Reduces Postischemic Myocardial Infarction and Improves Left Ventricular Performance via Activation of the Janus Activated Kinase-2/Signal Transducers and Activators of Transcription-3 Signal Pathway and Subsequent Inhibition of Glycogen Synthase Kinase-3β in Rats

Structured PICO

Implication

Abstract

Discussion

Cite This Study

Remifentanil Preconditioning Reduces Postischemic Myocardial Infarction and Improves Left Ventricular Performance via Activation of the Janus Activated Kinase-2/Signal Transducers and Activators of Transcription-3 Signal Pathway and Subsequent Inhibition of Glycogen Synthase Kinase-3β in Rats

Structured PICO

Implication

Abstract

Discussion

Cite This Study

Keep reading

Keep reading