Why the study?
Does remifentanil reduce infarct size in a rabbit model of myocardial ischemia-reperfusion?
Population
New Zealand White rabbits anesthetized with propofol subjected to 30 min regional myocardial ischemia and 3…
Comparison
Remifentanil administered as a transient… vs Control group receiving ischemia and reperfusion…
Design
Preclinical, Rabbits were randomly assigned to experimental groups
Follow-up
3 hours of reperfusion
Authors
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Transient pre-ischemic remifentanil may limit infarct size in rabbits; leaves open timing effects on preconditioning and clinical translation.
Does remifentanil reduce infarct size in a rabbit model of myocardial ischemia-reperfusion?
Transient pre-ischemic administration of remifentanil limits infarct size, but continuous administration attenuates the protective effects of ischemic preconditioning in a rabbit model.
Kuzume et al. (2004) studied this question.
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