Population
Anesthetized, open chest, male Wistar rats subjected to 30 minutes of occlusion and 2 hours of reperfusion
Comparison
Ischemic preconditioning with or without opioid… vs Control and ischemic preconditioning alone
Design
Preclinical, Assigned to 1 of 14 groups
Follow-up
2 hours of reperfusion
Authors
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Delta1-opioid receptor mediation of ischemic preconditioning in rats leaves clinical translation open; extends mechanistic insight in animal models only.
The cardioprotective effect of ischemic preconditioning in the rat heart is mediated specifically by delta1-opioid receptors, rather than delta2-, mu-, or kappa-opioid receptors.
Schultz et al. (1998) studied this question.
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