Why the study?
Does opioid receptor agonist pretreatment reduce infarct size in a rat model of myocardial infarction?
Population
Anesthetized open-chest male Wistar rats subjected to 45 minutes of left coronary artery occlusion and 2…
Comparison
Opioid agonists infused 15 minutes prior to… vs Infusion with either saline alone or dimethyl…
Design
Preclinical
Follow-up
2 hours of reperfusion
Authors
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δ₂ agonism may confer cardioprotection in rats; leaves open translation to human myocardial infarction.
Does opioid receptor agonist pretreatment reduce infarct size in a rat model of myocardial infarction?
Peripheral δ₂ opioid receptor activation by deltorphin II induces infarct size reduction in a rat model of ischemia/reperfusion injury.
Маслов et al. (2010) studied this question.
Synapse has enriched 3 closely related papers on similar clinical questions. Consider them for comparative context: