What question did this study set out to answer?

To investigate the expression profile, prognostic significance, tumor immune microenvironment associations, and therapeutic potential of NETO2 in oral squamous cell carcinoma.

November 5, 2025BMC CancerOpen Access

Research on the expression, prognostic value, and regulatory effects on immune microenvironment of NETO2 in oral squamous cell carcinoma

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Authors

JWJinhang Wang ZCZifeng Cui KYKaicheng Yang

Discussion

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Overview

Translational study reveals elevated NETO2 correlates with poor survival and immune remodeling in oral squamous cell carcinoma, highlighting its potential as a therapeutic target.

Key Points

To investigate the expression profile, prognostic significance, tumor immune microenvironment associations, and therapeutic potential of NETO2 in oral squamous cell carcinoma.
Analyzed NETO2 expression and patient survival across public datasets (TCGA and GEO cohorts) to establish Kaplan-Meier curves and a prognostic nomogram evaluated with ROC curves.
Characterized cell-specific expression and immune signaling with single-cell RNA sequencing, screened drug sensitivities alongside molecular docking, and verified tumor invasion, migration, and proliferation in vitro.
NETO2 was significantly overexpressed in tumor tissues, and elevated expression significantly correlated with shorter overall survival and progression-free survival, with nomogram AUC values exceeding 0.66 for 1-, 3-, and 5-year survival.
Single-cell analyses demonstrated elevated NETO2 within T cell clusters linked to cytokine and T cell receptor signaling pathways, alongside higher immune infiltration and differential drug sensitivity in high-expression tumors.
In vitro functional assays confirmed that NETO2 promotes oral squamous cell carcinoma proliferation, migration, and invasion, while molecular docking indicated strong binding affinities with compounds including ruxolitinib, paclitaxel, and docetaxel.

Cite This Study

Wang et al. (2025) studied this question.

synapsesocial.com/papers/6a8da17f0b453ccb7788e6bb https://doi.org/10.1186/s12885-025-15164-y

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November 5, 2025BMC CancerOpen Access

Research on the expression, prognostic value, and regulatory effects on immune microenvironment of NETO2 in oral squamous cell carcinoma

View Full Paper

Ask AI

Bookmark

Authors

JWJinhang Wang ZCZifeng Cui KYKaicheng Yang

Discussion

Member takes

Overview

Translational study reveals elevated NETO2 correlates with poor survival and immune remodeling in oral squamous cell carcinoma, highlighting its potential as a therapeutic target.

Key Points

To investigate the expression profile, prognostic significance, tumor immune microenvironment associations, and therapeutic potential of NETO2 in oral squamous cell carcinoma.
Analyzed NETO2 expression and patient survival across public datasets (TCGA and GEO cohorts) to establish Kaplan-Meier curves and a prognostic nomogram evaluated with ROC curves.
Characterized cell-specific expression and immune signaling with single-cell RNA sequencing, screened drug sensitivities alongside molecular docking, and verified tumor invasion, migration, and proliferation in vitro.
NETO2 was significantly overexpressed in tumor tissues, and elevated expression significantly correlated with shorter overall survival and progression-free survival, with nomogram AUC values exceeding 0.66 for 1-, 3-, and 5-year survival.
Single-cell analyses demonstrated elevated NETO2 within T cell clusters linked to cytokine and T cell receptor signaling pathways, alongside higher immune infiltration and differential drug sensitivity in high-expression tumors.
In vitro functional assays confirmed that NETO2 promotes oral squamous cell carcinoma proliferation, migration, and invasion, while molecular docking indicated strong binding affinities with compounds including ruxolitinib, paclitaxel, and docetaxel.

Cite This Study

Wang et al. (2025) studied this question.

synapsesocial.com/papers/6a8da17f0b453ccb7788e6bb https://doi.org/10.1186/s12885-025-15164-y

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