Key result
Late midpoint of sleep was associated with a 16% higher odds of type 2 diabetes (OR 1.16) compared to an intermediate midpoint, and the combination of late midpoint and sleep duration ≥9 hours increased prevalence by 39%.
Why the study?
The study was conducted to explore the independent and combined associations of midpoint of sleep and night sleep duration with type 2 diabetes mellitus in areas with limited resources.
Does early or late midpoint of sleep and long night sleep duration increase the prevalence of type 2 diabetes mellitus in a Chinese rural population?
Cross-Sectional (n=37,276)
Yes
Does early or late midpoint of sleep and long night sleep duration increase the prevalence of type 2 diabetes mellitus in a Chinese rural population?
Odds Ratio: 1.16 (95% CI 1.05–1.28)
Both early and late midpoints of sleep, as well as long night sleep duration, are independently and jointly associated with a higher prevalence of type 2 diabetes mellitus in a rural Chinese population.
Extreme sleep timing and prolonged duration are associated with higher T2DM prevalence; leaves open whether modifying sleep.
Background: The study aimed to explore the independent and combined associations of midpoint of sleep and night sleep duration with type 2 diabetes mellitus (T2DM) in areas with limited resources.Methods: A total of 37,276 participants (14,456 men and 22,820 women) were derived from the Henan Rural Cohort. Information on sleep were collected using the Pittsburgh Sleep Quality Index. Logistic regression models and restricted cubic splines were used to estimate the relationship of the midpoint of sleep and night sleep duration with T2DM.Results: Of the 37276 included participants, 3580 subjects suffered from T2DM. The mean midpoint of sleep among Early, Intermediate and Late groups were 1.09 ± 0.39, 1.93 ± 0.24 and 2.95 ± 0.56, respectively. Compared to Intermediate group, adjusted odd ratios (ORs) and 95% confidence interval (CI) of T2DM were 1.13 (1.04-1.22) and 1.16 (1.05-1.28) in Early group and Late group. Adjusted OR (95% CI) for T2DM compared with reference (7- h) was 1.27 (1.08-1.50) for longer (≥10 h) night sleep duration. The combination of late midpoint of sleep and night sleep duration (≥9 h) increased 39% (95% CI: 11%-75%) prevalence for T2DM. These associations were more obvious in women than men.Conclusions: Late and early midpoint of sleep and long night sleep duration were all associated with the higher odds of T2DM. Meanwhile, midpoint of sleep and night sleep duration might be jointly associated with a higher prevalence of T2DM. Sleep may be a modifiable behavior that has potential health implications for T2DM.Clinical Trail Registration: The Henan Rural Cohort Study has been registered at Chinese Clinical Trial Register (Registration number: ChiCTR-OOC-15006699). Date of registration: 2015-07-06.
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Zhai et al. (2021) conducted a cross-sectional in Type 2 Diabetes Mellitus (n=37,276). Late midpoint of sleep vs. Intermediate midpoint of sleep was evaluated on Prevalence of Type 2 Diabetes Mellitus (OR 1.16, 95% CI 1.05-1.28). Late midpoint of sleep was associated with a 16% higher odds of type 2 diabetes (OR 1.16) compared to an intermediate midpoint, and the combination of late midpoint and sleep duration ≥9 hours increased prevalence by 39%.
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