Key result
In men with asymptomatic carotid stenosis, a history of coronary artery disease was associated with a higher rate of cardiac ischemic events compared to no history of CAD (43% vs 33%; P=0.03).
Why the study?
Do men with asymptomatic carotid stenosis and no history of CAD have the same cardiac prognosis as those with a history of CAD?
RCT (n=444)
randomized
Yes
Do men with asymptomatic carotid stenosis and no history of CAD have the same cardiac prognosis as those with a history of CAD?
Absolute Event Rate: 43% vs 33%
p-value: p=.03
Men with asymptomatic carotid stenosis and no history of CAD generally have fewer cardiac events than those with CAD, unless they have coexistent diabetes, intracranial occlusive disease, or peripheral vascular disease.
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CAD history may refine cardiac risk estimates in asymptomatic carotid stenosis; leaves open comorbidity-adjusted prognosis and prospective validation.
Chimowitz et al. (1994) conducted an RCT in asymptomatic carotid stenosis (n=444). History of coronary artery disease vs. No history of coronary artery disease was evaluated on cardiac ischemic events (angina, myocardial infarction, or sudden death) (p=.03). In men with asymptomatic carotid stenosis, a history of coronary artery disease was associated with a higher rate of cardiac ischemic events compared to no history of CAD (43% vs 33%; P=0.03).
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