A mapping is established between sequence alignment, one of the most commonly used tools of computational biology, at a certain choice of scoring parameters and the asymmetric exclusion process, one of the few exactly solvable models of nonequilibrium physics. The statistical significance of sequence alignments is characterized through studying the total hopping current of the discrete time and space version of the asymmetric exclusion process.
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Ralf Bundschuh (2002) studied this question.
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