Prognostic value of near-infrared spectroscopy in mortality and organ dysfunction in patients recovery from septic shock: The research protocol

Background: Sepsis or septic shock results in the alteration of blood flow at the microcirculatory level, affecting tissue oxygenation and organ function and associated with death. This study aimed to use near-infrared spectroscopy (NIRS) in conjunction with vascular occlusion test (VOT) to assess the association of microcirculatory dysfunction after recovered from septic shock and in-hospital mortality. Methods: We conducted a prospective observational study in patients who recovered from septic shock. We performed NIRS with VOT within 24 hours of hospitalization in medical and anesthetic ICU (T0), then at the time of recovery from septic shock (D0), at day 3 (D3), day 5 (D5), and day 7 (D7) after recovery from septic shock. We recorded the de-oxygenation (DeO2) slope, the re-oxygenation (ReO2) slope, and the area under the hyperemic response curve (the reperfusion area). We focused on parameters of microcirculation dysfunction, in-hospital mortality, and in-hospital complications. Hypothesis: We hypothesize that NIRS with vascular occlusion test parameters are associated with in-hospital mortality and hospital complications Ethic: The study protocol has been approved by the Institution Review Board of Ramathibodi Hospital, Mahidol University, Thailand (No. MURA2020/147). Trial registration: TCTR20220413001