Why the study?
Thyrotoxic periodic paralysis can be clinically indistinguishable from other causes of hypokalemia, but requires specific management considerations that could otherwise easily go unaddressed.
Case Report (n=1)
No
Thyrotoxic periodic paralysis is a rare cause of hypokalemia that requires cautious potassium repletion and non-selective beta-blockers to resolve symptoms and avoid rebound hyperkalemia.
Highlights the need to consider thyrotoxicosis in acute hypokalemic paralysis to avoid mismanagement;.
Thyrotoxic periodic paralysis (TPP) is a unique cause of hypokalemia from transcellular shift into muscle in the setting of active thyrotoxicosis. It is essential to recognize TPP, given the specific management considerations, which would otherwise easily go unaddressed. TPP can also be clinically indistinguishable from other causes of hypokalemia. In particular, familial periodic paralysis can present similar to TPP. This case illustrates a young Hispanic male who presented with paralysis and was found to be hypokalemic. Patient was also found to have thyromegaly with further testing consistent with Grave's disease, despite no hyperthyroid symptoms. Ultimately, identifying TPP early will allow for swift and appropriate treatment, avoid unnecessary interventions and testing, and reduce cost of care.
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Mabile et al. (2021) conducted a case report in Thyrotoxic Periodic Paralysis (TPP) and Grave's Disease (n=1). Potassium chloride and propranolol was evaluated on Resolution of weakness and correction of hypokalemia.
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